That was weird

NINWithTeeth.jpgI lost a day, I have no idea where I lost it. But when I woke up this morning, It was a day later than I thought it should be.

Did I sleep a full 24 hours?

I was reminded of NIN “Every Day is Exactly the same”

I know that I didn’t sleep 24 hours, but all my days are running into one another. I guess it’s just that there’s nowhere to go and I’m rapidly losing interest in doing anything around the house.

It’s not that I don’t have stuff to do, It’s that more often than not, when I’m in the midst of doing something I realize that I need something from a store that’s either closed or a place where I’m going to have to stand in line for 30 minutes to get into, or out of the place, possibly both. If all I need is something dumb like a bolt or screws it’s not worth the effort or annoyance. So the project dies right there. 

I’ve been trying to put things on my lists so that when I go somewhere I’m picking up all the little bits at once preferably in one store. Otherwise a mult-store run turns into a whole day affair and the herd tension of the crowds makes me very uncomfortable.

Even the outdoor carwash isn’t working properly. There’s no soap in the spritzer, and many of the wash bays are no longer functional. It’s not like you’re going to violate social distancing and the way the wind whips through the place the likely-hood of contamination is pretty darn low.

But trying to wash the car wear a mask, not have your glasses or sunglasses fog up, plus the lack of soap or working bays has taken even the simple pleasure of washing my car to the depths of despair. 

There are some things that may not be essential services, but they should be allowed to remain open for the positive psychological benefits. I may just wash the car in the front drive, California water restrictions be damned.

At least I’d be outside and doing something different.

Okay, So with all the Chloroquine hubub…

800px-Medical_quinolines_pathway.pngI got curious. 

There has been a lot of wailing and gnashing of teeth about this drug.

Yes, it’s a drug and guess what, it’s listed as an essential drug by the World Health Organization.

OMG! You mean Trump didn’t just pull it out of his ass?

Nope! He didn’t. Before you go off on the other now debunked report that Trump has stock in manufacturers of this drug, Just STOP!

I knew it’s primarily used as an anti malarial drug. But Malaria is caused by a parasite, not a virus. Hmmm, so what the hell?

Well it turns out that it’s also used for autoimmune diseases like rheumatoid arthritis and lupus erythematosus. Why? because Chloroquine has a depressing effect on the immune system. 

Wait a minute… If it depresses the immune response it makes no sense to use it with a viral infection. If someone is sick, it’s counterintuitive to actively depress their immune system. 

Chloroquine has been known since 1934. Its analog organic origin was originally obtained from tree bark by the indigenous people of Peru, before 1633. They used it as an extract to fight fever and chills. It was introduced to Europe after 1633 as a treatment against Malaria. It was called Quinine.

While I was in the shower, My head locked on quinine. That was familiar to me and I knew it was in my household I just couldn’t place it. Another minute researching with Wikipedia and BOOM! 

Same bark, same tree, same indigenous people and known to the Spanish as early as 1571 to have medicinal properties. 

Cinchona bark was exported by the Spanish to Europe, Remijia bark produces lower quantities of Quinine but has a stronger taste. It’s used to flavor Tonic Water.

Don’t you Gin & Tonic drinkers get too excited, the levels are a bit too low to be medicinal. However, essentially you’ve got 400 years of research on Quinine. 

Chloroquine is a synthetic with a different chemical signature, that came into wide use around 1947.

Naturally occurring quinine is C20H24N2O2. Chloroquine is C18H26ClN3 They’re different but similar chemistry. Chloroquine is a synthetic analog of Quinine.

You have to read much further into the article to find out how all this relates to Coronavirus.

2560px-Chloroquine.svg.pngBy the way, the Wikipedia article is here.

Fairly late in the article there’s an explanation of the antiviral effects of Chloroquine.

Because of the way Chloroquine affects the PH of organelles within a cell it tends to prevent a virus from releasing its genetic material.

Since the virus can’t release its RNA, it can’t infect a cell to convert the cell to replicate more viruses. Chloroquine also does something to Zinc uptake in the cell which inhibits RNA functions too.1920px Chloroquine 3D structure

I’m not a biologist, but I know that the basic way a virus reproduces is by hijacking the DNA of a cell, essentially reprogramming the cell to stop doing normal cell stuff and start using all the cellular resources to make viruses. It does this by putting its RNA into the cell. That’s how it reprograms cellular function.

When the cell runs out of resources it dies, then the cell membrane ruptures releasing all the viruses its built into surrounding cells. That’s how the infection continues.

So if you’re able to prevent the virus from hijacking healthy cells to begin with, you end the infection. The body then has time to identify and destroy the inert virus material floating around.

Remember DNA and RNA are related and if memory serves, interact during cellular reproduction. 

Since Chloroquine is absorbed quickly by the body and is distributed rapidly in the bloodstream it’s like a big off switch to the virus invasion. That’s possibly why so many people have reported that they or their loved ones were on death’s door and had such amazing recoveries after being given Chloroquine.

The news isn’t all rosy. Chloroquine can have nasty side effects and it can become toxic easily. That’s why careful monitoring is required and only doctors prescribe it. It also can interact with other drugs and cause other problems.

The side effects of the drug are many, and include problems with vision, nausea, vomiting, abdominal cramps, headache, diarrhea, shortness of breath, muscle weakness and the list goes on. 

Make no mistake Chloroquine is a powerful drug and as with any powerful medication there is a possibility that it could cause more harm than good.

That being said. If I’m on my deathbed, what the hell do I have to lose?

So in conclusion, this is a drug that’s been around for many years. Its effects are fairly predictable and its side-effects and countermeasures are well known and researched. 

All the information about the drug is readily available on the internet in less than five minutes (even if you misspell the name).

There are two versions of it. One is Chloroquine and the other is Hydroxychloroquine I don’t know, and am not qualified, to evaluate the differences or provide explanation as to why there are variations. However both appear to have been derived from a 400 year old, or older natural organic remedy called Quinine.

It may be something as simple as one is more effective or easier on the system.

Apparently, Chloroquine was investigated during the SARS outbreak and there was a report published that is appeared to have efficacy against SARS in vitro. 

SARS is also caused by a Coronavirus.

It’s entirely logical that the medical people would have gone back to the publications and research done on any Coronavirus, looking for something that would be effective at least in slowing Coronaviruses to buy time during treatment. Remember slowing the progress of a disease gives the body time to construct an immune defense.

This information would have been presented to the President and his advisors when coronavirus first hit the world stage. The President probably shouldn’t have been as excited about the possibility of an untested treatment. But he at least was able to tell the American people that all was not lost, coronavirus infection was not a death sentence and to have hope.

Yes, there haven’t been any clinical trials yet. Clinical trials take time. Half the group you give the drug, and half the group you give a placebo then you tally the results to determine effectiveness.

Tell me, how many of you would want to participate in a clinical trial during a pandemic? How many of you would want to be sick and be getting sugar pills instead of something that at least anecdotally was working?

Uh huh, I didn’t think so…

Now can we please stop all the bitching and complaining about the President saying anything about Chloroquine or Hydroxychloroquine?

The other question I have is this… If a dumbshit like me can look up this information and understand in at least a rudimentary way how the drugs work;

WHY THE HELL CAN’T PROFESSIONAL JOURNALISTS?

Just saying…

Bwhahahahah! There are some things that tickle the hell out of me!

CNN: Wanted: People who know a half century-old computer language so states can process unemployment claims.

willcodeforfood.jpegI saw this and just about laughed myself stupid.

I thought, “New Jersey is going to have to check homeless camps, ask old bartenders, check with real estate agents, lawyers, and gas station attendants.”

That’s where most of the old COBOL or FORTRAN programmers ended up, all of whom were laid off in favor of H1B1s. Yep, a lot of those programmers were tossed aside like yesterday’s trash by businesses, and government back in the 80’s.

manonbench.jpegA lot of them moved on to other things and I know several that built lucrative businesses in other fields. For a while I had an Eye doctor that had been a COBOL programmer. He was making way better money as an eye doctor than he ever made as a programmer and the hours were better too.

He didn’t regret getting out of programming at all. Like most of us old school tech people, he’d gone through lay off, after lay off, and had “trained” his replacements at too many companies.

homelesstents.jpegHe went back to school after his last layoff, graduated and started his own practice. To do this, he lived in a leaky teardrop trailer for two years after cashing out everything he owned to pay for school. He wasn’t eligible for student loans because he’d made too much in his previous positions.

I know some real estate agents and a couple of patent attorneys as well. They were all great programmers and they were treated like shit.

Iusedtobeyourneighbor.jpegThey wouldn’t touch a programming job now. It brings back bitter memories for them to even talk about programming.

See, they loved what they were doing, they had their joy crushed and were considered disposable in favor of “cheap” labor. Many of them simply walked off the job rather than “train” their foreign replacements.

I say “train” because more often than not the foreign replacements weren’t up to snuff to begin with. Many of these folks couldn’t follow the code, so training was a pointless exercise.

Then I remembered Y2K and thought it’s been 20 years. Couldn’t these government entities be bothered to update the equipment and programs? 

Some of the COBOL guys did come back to rework Y2K systems and they charged frankly obscene amounts to do it. I’d heard that several paid off houses and cars loans with the money they earned from Y2K contracts.

Then I thought, “Who’s gonna test it?”

I went back to laughing.

I’m sorry that the people in need of unemployment benefits aren’t going to be helped it’s not fair to them. However, this brings into sharp relief, other problems “leaders” in business and government have been sweeping under the carpet for decades.

The chickens are coming home to roost.