Category: Entertainment

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Okay, So with all the Chloroquine hubub…

800px-Medical_quinolines_pathway.pngI got curious. 

There has been a lot of wailing and gnashing of teeth about this drug.

Yes, it’s a drug and guess what, it’s listed as an essential drug by the World Health Organization.

OMG! You mean Trump didn’t just pull it out of his ass?

Nope! He didn’t. Before you go off on the other now debunked report that Trump has stock in manufacturers of this drug, Just STOP!

I knew it’s primarily used as an anti malarial drug. But Malaria is caused by a parasite, not a virus. Hmmm, so what the hell?

Well it turns out that it’s also used for autoimmune diseases like rheumatoid arthritis and lupus erythematosus. Why? because Chloroquine has a depressing effect on the immune system. 

Wait a minute… If it depresses the immune response it makes no sense to use it with a viral infection. If someone is sick, it’s counterintuitive to actively depress their immune system. 

Chloroquine has been known since 1934. Its analog organic origin was originally obtained from tree bark by the indigenous people of Peru, before 1633. They used it as an extract to fight fever and chills. It was introduced to Europe after 1633 as a treatment against Malaria. It was called Quinine.

While I was in the shower, My head locked on quinine. That was familiar to me and I knew it was in my household I just couldn’t place it. Another minute researching with Wikipedia and BOOM! 

Same bark, same tree, same indigenous people and known to the Spanish as early as 1571 to have medicinal properties. 

Cinchona bark was exported by the Spanish to Europe, Remijia bark produces lower quantities of Quinine but has a stronger taste. It’s used to flavor Tonic Water.

Don’t you Gin & Tonic drinkers get too excited, the levels are a bit too low to be medicinal. However, essentially you’ve got 400 years of research on Quinine. 

Chloroquine is a synthetic with a different chemical signature, that came into wide use around 1947.

Naturally occurring quinine is C20H24N2O2. Chloroquine is C18H26ClN3 They’re different but similar chemistry. Chloroquine is a synthetic analog of Quinine.

You have to read much further into the article to find out how all this relates to Coronavirus.

2560px-Chloroquine.svg.pngBy the way, the Wikipedia article is here.

Fairly late in the article there’s an explanation of the antiviral effects of Chloroquine.

Because of the way Chloroquine affects the PH of organelles within a cell it tends to prevent a virus from releasing its genetic material.

Since the virus can’t release its RNA, it can’t infect a cell to convert the cell to replicate more viruses. Chloroquine also does something to Zinc uptake in the cell which inhibits RNA functions too.1920px Chloroquine 3D structure

I’m not a biologist, but I know that the basic way a virus reproduces is by hijacking the DNA of a cell, essentially reprogramming the cell to stop doing normal cell stuff and start using all the cellular resources to make viruses. It does this by putting its RNA into the cell. That’s how it reprograms cellular function.

When the cell runs out of resources it dies, then the cell membrane ruptures releasing all the viruses its built into surrounding cells. That’s how the infection continues.

So if you’re able to prevent the virus from hijacking healthy cells to begin with, you end the infection. The body then has time to identify and destroy the inert virus material floating around.

Remember DNA and RNA are related and if memory serves, interact during cellular reproduction. 

Since Chloroquine is absorbed quickly by the body and is distributed rapidly in the bloodstream it’s like a big off switch to the virus invasion. That’s possibly why so many people have reported that they or their loved ones were on death’s door and had such amazing recoveries after being given Chloroquine.

The news isn’t all rosy. Chloroquine can have nasty side effects and it can become toxic easily. That’s why careful monitoring is required and only doctors prescribe it. It also can interact with other drugs and cause other problems.

The side effects of the drug are many, and include problems with vision, nausea, vomiting, abdominal cramps, headache, diarrhea, shortness of breath, muscle weakness and the list goes on. 

Make no mistake Chloroquine is a powerful drug and as with any powerful medication there is a possibility that it could cause more harm than good.

That being said. If I’m on my deathbed, what the hell do I have to lose?

So in conclusion, this is a drug that’s been around for many years. Its effects are fairly predictable and its side-effects and countermeasures are well known and researched. 

All the information about the drug is readily available on the internet in less than five minutes (even if you misspell the name).

There are two versions of it. One is Chloroquine and the other is Hydroxychloroquine I don’t know, and am not qualified, to evaluate the differences or provide explanation as to why there are variations. However both appear to have been derived from a 400 year old, or older natural organic remedy called Quinine.

It may be something as simple as one is more effective or easier on the system.

Apparently, Chloroquine was investigated during the SARS outbreak and there was a report published that is appeared to have efficacy against SARS in vitro. 

SARS is also caused by a Coronavirus.

It’s entirely logical that the medical people would have gone back to the publications and research done on any Coronavirus, looking for something that would be effective at least in slowing Coronaviruses to buy time during treatment. Remember slowing the progress of a disease gives the body time to construct an immune defense.

This information would have been presented to the President and his advisors when coronavirus first hit the world stage. The President probably shouldn’t have been as excited about the possibility of an untested treatment. But he at least was able to tell the American people that all was not lost, coronavirus infection was not a death sentence and to have hope.

Yes, there haven’t been any clinical trials yet. Clinical trials take time. Half the group you give the drug, and half the group you give a placebo then you tally the results to determine effectiveness.

Tell me, how many of you would want to participate in a clinical trial during a pandemic? How many of you would want to be sick and be getting sugar pills instead of something that at least anecdotally was working?

Uh huh, I didn’t think so…

Now can we please stop all the bitching and complaining about the President saying anything about Chloroquine or Hydroxychloroquine?

The other question I have is this… If a dumbshit like me can look up this information and understand in at least a rudimentary way how the drugs work;

WHY THE HELL CAN’T PROFESSIONAL JOURNALISTS?

Just saying…

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Truly one of the sickest things I’ve ever read.

A jury in Texas has ruled against a father in a custody battle leaving the door open for the mother of a 7 year old boy in Texas (One of a set of male twins) to pursue at her option, the transition of one twin boy to a female. 

Here is an opinion piece from The Washington Examiner

Here is a news piece from The Washington Examiner

Here is the report from KPRC in Texas

Here is a report from Lifesitenews

Here is a link to a website dedicated to the boy

Here is a link to Chad Felix Greene’s article in The Federalist

UPDATE

Judge rules that the father of James Younger will be allowed to Veto medical intervention. In other words, the father has not been stripped of all parental rights.

Read More here

Oddly, I wasn’t able to find coverage on NBC, ABC, CNN, CBS or more than the briefest mention of it in local Texas papers. It is somewhat unsurprising that only “conservative” outlets are carrying the story.

A 7 year old?

WHAT?

It’s not even clear that the child has gender dysphoria. At 7 isn’t it natural, perhaps even expected for children to be curious about what it’s like to dress up? The experts in the case say the childs gender is still fluid.

Reading through the available, and no doubt biased, information points to a bitter divorce… correction annulment. I suspect that the annulment is a farce and that there is still some kind of pitched legal battle behind the scenes ongoing. To my rather suspicious mind it begs the questions, “Is the mother trying to use the child as a weapon? Is she willing to harm a child in order to harm the father?” The truly amazing thing is that she’s not the twins biological mother.  Yes she gave birth to the boys, but the eggs were not her own. 

Add to this, several years ago there was the case, in Seattle I believe, where biological parents (who happened to be Native Americans) won custody of a child. In this case the child had been given up at birth. The child had been adopted by a white suburban family and had never known anything other than that family. But the state in it’s infinite wisdom ordered the child surrendered to the Native American parents based on the biological connection.

By that logic, in the case of James, his father Jeffery should have a greater claim to custody of the two boys. 

After all, at its heart this is a custody battle. It’s a father acting to protect one of his children from medical procedures that will have permanent, potentially negative effects. Isn’t this what custody battles are all about, or at least what they should be about?

I suppose what’s shocking to me is that the jury ruled against the father. 

My shock is not about Transphobia, this is about a child who frankly is too young to understand the hubub and for whom nature should probably be allowed to take it’s course at least until the child can specifically say, “I want to be a girl.”

I have many reservations about transitioning children’s genders because of the long term physical damage. Think about it. Hormone replacement therapy is a lifelong commitment, and potentially life shortening in the case where you’re fighting the fundamental programming of the human body. Would any parent wish that for their child who didn’t need it, or was uncertain of the child’s wishes?

I found myself nodding as I read the opinion piece (above) by Brad Polumbo

This “transgender radicalism” has gone on long enough and been allowed to go too damn far.

Let children be children. All of us need to stop putting our hangups, fears, hatred, confusion, or political statements on them. 

Our duty as adults, Straight, Gay, Transgendered, White, Black, Yellow, Red, Brown, whatever, is to protect children, any children, because they can’t protect themselves. 

That means protecting their lives, innocence, and childhood, until they are ready to make their own choices. Even then, when they make poor choices and stumble, it is our duty to pick them up, dust off their clothes, put a band-aid on their boo boos (emotional, physical, or both) and tell them to try again.

That’s what being an adult is.

It depresses the shit out of me that so many so called “Adults” have forgotten that simple duty or have been terrorized into silence.

There used to be a saying, “There’s nothing worse than an X-smoker”. That statement is often true about an X anything. X- Smokers tend to be rabid about other people smoking, X-overweight people tend to point out what others are eating as fattening. 

Perhaps X-Binary Genders are engaging in something similar? “ I’m happier now that I’ve transitioned and therefore everyone would be happier if they did too”

It’s a question that has more than once flitted through my mind.

I’m quite happy being a male. I like my body, (well except for the few creeping pounds of age). I like my genitalia and have no desire to change. (Well, larger would be nice, ahem) I recognize that may not be true of all people and your choice, is to make changes to your own bodies as you desire.

BUT, don’t you dictate my choices, or impose your beliefs about what I should feel or want, or how I should express my sexuality. 

You see I, as an adult have to personal strength and conviction to say that, and the ability to defend my statement, just as you do. 

Can the same be said of a child?

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OK So yesterday wasn’t so Quiet…

Doctor

Got done at the Doc’s.

(No Happy Ending!)

Apparently I was alive enough for the Doc to be confident that I wasn’t going to drop dead in his office.

Yesterday was the first time that my Doc mentioned anything about politics. Apparently, he’s still hopping mad about Trump. I told him I don’t watch the News anymore, and joked, that it’s obviously helped my blood pressure.

He asked how I stayed informed. I told him I read the news because it’s a lot easier to limit my exposure to shit that pissed me off. He said what about Trump? I told him I thought Trump was simply the latest in a long line of politicians who as my grandfather used to say, “are all crooks and liars.” 

My Doc said he loved Obama… 

I said I didn’t love any of our politicians, because they all too easily forgot their job was to be in service to all the people. I’d be happier if they said what they mean, did what they said, and always put the needs of all the people who elected them, first.

There was an uncomfortable silence and we moved back into the professional comfort of the Doctor, Patient relationship.

Traffic

I was glad, because on Obama and the Democratic party, my Doctor and I are poles apart. That doesn’t mean I think my Doctor is a bad guy, or necessarily completely wrong.  I was however, suddenly concerned that he might just be so angry about the current state of our political system, that he might lose sight of the fact that I’m not a bad guy either.

In all honesty, we’re both probably operating from misinformation and the truth is somewhere between our two points of view. More importantly, he’s a good doctor and someone that I value having in my life.

I guess I valued the relationship we’ve built over the years more than the desire to swing him over to my opinion. I suspect that he may have reached the same conclusion.

FLU SHOT

All I can say is that I’m really glad that my hunger hadn’t reached the point that I wasn’t thinking. Otherwise the situation could have gone badly.

I’m really sad that the political polarization in our country is permeating into every aspect of daily life. Politics used to be something you bitched about in a bar with your friends, half drunk. Now it’s almost everywhere and 24/7. I mean who gives a fuck? Those assholes in Washington and the Statehouses across the nation are more than likely in someone’s pocket. The only voice we have is voting and that voice is growing weaker each election cycle. It’s been demonstrated that elections can be affected, not only by foreign governments, but also by a media who is not adhering to good journalistic practices. Thank goodness I thought this instead of speaking it.

Flu

By the time I was done, I was starving. So I thought I’d head out to get something to eat immediately. Traffic was a nightmare!  After sitting on the freeway, (Thats a mis-named thing if ever there was one) for about 45 minutes I noticed I was close to a place I used to have my hair cut. I figured, “What the hell,” and pulled in. They had an opening and soon I was in the chair having my mop cropped. Still very, very, hungry.  

WOW! The prices had gone up… Should’ve checked that before I sat in the chair. A couple of years ago the prices were obscene, NOW, the prices are astronomical! Grrr!

Why is it that you can’t get a decent haircut at a reasonable price anymore? I don’t want anything fancy, I just want consistent.  I’ve tried many places in Escondido & San Diego and you’re lucky if the same person is working at the place from month to month. The phenomena isn’t limited to San Diego, it’s everywhere. I was noticing it long before I moved out of the OC / Riverside area. I don’t like clipper cuts, I like scissor cuts. Clipper cuts accentuate the cowlicks I have and frankly, I could probably give myself a clipper cut. 

Iu

Anyhow, the stylist did a pretty good job, at least it’s workable. Maybe I can find a hairburner in San Diego that can maintain the cut. If that fails, I’m going to be heading to a stylist in Beverly Hills that comes highly recommended by several friends.  Who, believe it or not… is cheaper than the place I was at yesterday.

Still hungry, I get back on the misnamed road called a freeway. Traffic was better and the further I got out of southern OC the better it got. Pretty soon, I could see the mountains I call home. 

Got in the door, started wolfing down junk food, then started laundry.

Shutting down the irrigation system had to wait until today. 

However, I’m moving very slow today. Maybe the flushot I got yesterday. Not that I feel sick, but I do feel super tired. That’s probably the immune response kicking in, creating antibodies to fight off the faux infection. It’ll pass in the next day or two.

Gotta get a move on, the day is passing and I’m done with the weeks laundry.

Have a great weekend.

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OH Shut the hell up!

I wake up, get coffee, wake up the computer, sit down…

The very first thing I see as I’m firing up my browser to check which bills need to be paid is an AP headline article. 

Trump family dinner raises issues on press access

You have got to be freaking kidding me!

Other articles report it like, Trump leaves his Dark Tower.

Sauron 2

Really? So you’re using a literary allusion implying that President Elect Trump is Sauron from the Tolkien classics.  Oh For pete’s sake.

The man hasn’t taken his oath of office, he’s the President Elect, not the President yet. 

And let’s face it Journalists, you haven’t done anything to endear yourselves to the President Elect. Is it really all that surprising that he’d like to have a dinner with his family away from your scrutiny?

After all how many poison pens have you emptied on how many thousands of reams of paper trying to tear the man and his family down.

God knows, I wouldn’t want to have my food turn to ash on my tongue (obscure literary allusion) because some reporter saw me not using a salad fork.

I can see that headline.

Can wwducat be trusted at state dinners, he doesn’t know which fork to use!

 Look Journalists…

You’ve betrayed the public trust. You’ve been caught time and again displaying incredible bias over the past eight years. That is your responsibility, you have no-one to blame but yourselves. So it’s time for you to own it.

Decide if you want to continue to be yellow journalists or if you want to move back toward being the folks the nation looks to for truth.

Mordor

I’m sorry, but it’s going to take consistent unbiased fact checking, for years, to regain the people’s trust. The mistakes and excesses of  the past will be visited upon newly minted journalists, today and well into the future.

Stop looking for the fluff pieces. WHO the hell cares if Trump goes to dinner with his family away from prying eyes? Why does that matter?

If you must report on the President Elect; report on his cabinet postings, his advisors, his plans for uniting the country, improving the economy, and all the other major issues we face.

You might begin by being polite and checking your privilege. It probably wouldn’t hurt if you quit your whinging about being shunned as well. 

We don’t need moment by moment coverage of the President Elect’s flatulence.

We need you to understand that the duty of your profession is to provide information.

That information, should consist of simply the facts of a situation with as little personal opinion or bias as possible.

You’re rather tough job is to report what you see and what you’ve discovered via investigation, not hearsay. Then you must leave it to the people to decide what they want to do with the information. It’s a tough job, and often thankless, but it’s a vital job to ensure the freedoms we enjoy in this country.

Recently, you’ve gone wrong; a bit off the rails… Fortunately, Americans are generally forgiving and it’s not too late to regain the respect that you one enjoyed.

If you want to express your opinions write Op-Ed pieces. Otherwise keep your opinions to yourselves and report the facts.

Just my opinion…

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Thank God I didn’t see this live

There are times when you just have to appreciate the bluntness of a military man.

Retired U.S. Army Lt. Col. Ralph Peters didn’t mince words Monday when asked about President Obama’s strategy on tackling and destroying ISIS — and was suspended by Fox News for it.
– via Guns.com

When I watched the video and Lt. Col Peters delivered his comment I’m very glad that I wasn’t eating or drinking anything. I’d have choked to death!

“Look, Mr. President we’re not afraid we’re angry, we’re pissed off, we’re furious,” Peters said. “We want you to react, we want you to do something. You’re afraid. I mean this guy is such a total pussy, its stunning. And, you know, we want — we the people, the American people, whom he does not know in any intimate sort of manner, we want action. We want action against Islamic State and then — then, when the president is telling us he is going to destroy ISIS.”
– via Guns.com

Here is the video, Enjoy it.

https://youtu.be/ARkeDYFtDMk
I found it interesting that the Fox Anchor didn’t stop the Lt Col. until the Lt. Col. called the people in Ferguson, MO “Thugs”.